Basis, indications and risk
Epidural injections
It consists of the injection of steroid anti-inflammatory agents
derived from cortisone, and/or local anesthetics in the medullary
canal, in the area surrounding the membranes that cover the medulla.
This area is called the epidural space.

Upper view of a vertebra
1. Lamina
2. Spinous process
3. Transverse process
4. Vertebral body
5. Vertebral canal
Objective
To reduce inflammation, especially of the nerve
roots, and improve pain.
Theoretical base
Nerve root inflammation is sometimes produced by compression,
this being the cause for the onset of radiated pain. Cortisone derivatives
have a potent anti-inflammatory effect, although their risks and
contraindications do not allow a continued administration. When
generally administered, only a portion of the administered dose
reaches the swollen areas. To increase their anti-inflammatory effect
and to reduce risks, steroids are injected into the dural space
so as to obtain a potent local effect and less adverse reactions.
This significantly reduces nerve root inflammation and improves
radiating pain.
Administration of local anesthetics into the dural
space permits a major percentage of the administered dose to have
a full effect, thus improving the intensity of radiated pain.
Evidence of efficacy
Some of the early recommendations
based on scientific evidence indicated that epidural injections
have no effect in acute patients. However, later ones
that consider the results of more recent studies, state that epidural
steroid injections, with or without local anesthetics, appear to
produce better short-term relief of back pain with sciatica.
A study subsequent to those recommendations
shows that in patients with sciatica who are being considered for
surgery, epidural injections yield a temporary improvement, without
avoiding eventual surgery.
Risks and contraindications
Some of the existing recommendations
based on scientific evidence point out that epidural injections
are invasive and pose rare but serious potential risks. Common adverse
effects are headache, increased intensity of back pain and sciatica,
and fever. Inadvertent puncture of the dural membrane occurs between
0.5% and 2.5% of the cases. Exceptionally, dural abscesses or meningitis
have been reported following epidural injections.
Indications
The existing recommendations
based on scientific evidence do not include epidural injections
in standard managed care for back pain. Based on the available studies,
it may be wise to consider their use on patients, for temporary
relief of sciatica, when pain is intense and resistant to all other
treatments and when there is no indication for surgery.
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